Wharton’s Jelly

A Structural Matrix for Skin Recovery and Moisture Support

Wharton’s Jelly is a perinatal tissue component derived from the umbilical cord and used in Ascellos™ as a non-cellular, cosmetic-grade matrix. It contains hyaluronic acid, collagens, and structural proteins that help maintain moisture levels and support the outer skin environment. This ingredient supports post-procedural skin care by contributing to visible improvements in texture without involving live cells or biologic therapies.

What Is Wharton’s Jelly?

Wharton’s Jelly is a connective tissue located within the umbilical cord and composed of hyaluronic acid, collagens, and extracellular matrix proteins. It is collected after birth and processed into an acellular format to preserve its structure without including live cells or genetic material. In Ascellos™, this ingredient is used topically to support hydration, tissue quality, and visible skin renewal.

How Does Wharton’s Jelly Work?

Wharton’s Jelly contributes to cosmetic skin renewal by delivering matrix components and hydration factors that support repair, comfort, and post-treatment appearance.

  • Hydration: Hyaluronic acid in Wharton’s Jelly draws moisture to the skin surface, improving plumpness, elasticity, and visible softness.
  • Inflammation reduction: Cytokines and matrix proteins help calm surface-level irritation, supporting barrier comfort after cosmetic procedures.
  • Skin regeneration: Wharton’s Jelly supports the production of collagen and elastin, promoting dermal remodeling and a smoother, firmer texture.
  • Wound healing: Its growth factors encourage fibroblast activity and tissue recovery, helping the skin normalize more quickly after stress.
  • Barrier resilience: Topical application strengthens the skin’s outer layer, reducing post-procedural sensitivity and improving visible tolerance.

These effects support hydration, structure, and cellular communication using a non-injectable, cosmetic format aligned with FDA guidance.

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What Does Wharton's Jelly Do?

Wharton’s Jelly supports visible skin improvement by delivering matrix components and hydration agents that help restore surface comfort, texture, and structure.

  • Hydration: Hyaluronic acid in Wharton’s Jelly draws moisture to the skin surface, improving plumpness, elasticity, and visible softness.
  • Inflammation reduction: Cytokines and matrix proteins help calm surface-level irritation, supporting barrier comfort after cosmetic procedures.
  • Skin regeneration: Wharton’s Jelly supports the production of collagen and elastin, promoting dermal remodeling and a smoother, firmer texture.
  • Wound healing: Its growth factors encourage fibroblast activity and tissue recovery, helping the skin normalize more quickly after stress.
  • Barrier resilience: Topical application strengthens the skin’s outer layer, reducing post-procedural sensitivity and improving visible tolerance.

These effects support hydration, structure, and cellular communication using a non-injectable, cosmetic format aligned with FDA guidance.

What Does Wharton's Jelly Do?

Wharton’s Jelly supports visible skin improvement by delivering matrix components and hydration agents that help restore surface comfort, texture, and structure.

  • Enhanced hydration: Its hyaluronic acid content attracts moisture to the skin, helping restore hydration levels, improve suppleness, and ease post-treatment dryness.
  • Improved elasticity: Matrix proteins and growth factors encourage collagen synthesis, helping the skin maintain structure and recover firmness after cosmetic stress.
  • Reduced signs of aging: Wharton’s Jelly supports smoother texture and fewer visible fine lines by promoting structural protein renewal without live biologics.
  • Tissue repair and regeneration: Bioactive molecules assist with remodeling damaged skin, improving overall surface appearance and post-procedural recovery.
  • Anti-inflammatory properties: The matrix components help reduce visible redness and calm irritation, especially after microneedling or resurfacing procedures.
  • Wound healing support: Wharton’s Jelly may help accelerate barrier recovery and tissue closure when used in cosmetic care after controlled injury.
  • Immunomodulatory activity: Its acellular signals may help regulate local skin responses, contributing to a balanced and comfortable surface environment.
  • Non-cellular regenerative potential: Wharton’s Jelly provides structural and functional skin benefits without introducing stem cells or injectable materials.

These effects contribute to post-procedure hydration, recovery, and overall improvement in skin texture using a safe, topical cosmetic format.

Where Are They Used?

Wharton’s Jelly in Ascellos™ is applied topically to support hydration, texture improvement, and structural renewal in cosmetic skin treatments.

  • Under-eye rejuvenation: It helps improve elasticity, smooth fine lines, and reduce visible puffiness and dark circles in the periorbital area.
  • Acne scar protocols: Its matrix-based components promote collagen remodeling and tissue recovery, softening the appearance of atrophic scars.
  • Pigmentation and laxity support: Used to help even skin tone and reinforce dermal elasticity in areas with uneven color or early sagging.
  • Post-procedure recovery: Applied after microneedling, laser resurfacing, or peels to soothe the skin, restore hydration, and support surface healing.
  • Barrier repair in sensitive skin care: Integrated into gentle regimens to strengthen the skin barrier, ease dryness, and maintain moisture balance after cosmetic stress.

All Wharton's Jelly applications in Ascellos™ comply with FDA cosmetic guidelines for non-injectable use, targeting skin improvement without live cells or systemic delivery.

What Are The Considerations?

Wharton’s Jelly in Ascellos™ is a non-cellular, cosmetic matrix derived from umbilical tissue and formulated without therapeutic claims or live biologics.

  • Use classification: Wharton’s Jelly in Ascellos™ is applied topically and is not intended for injection, medical use, or systemic delivery.
  • Source and processing: It is derived from donated, medically screened umbilical cords and processed under controlled, sterile conditions following cGMP standards.
  • Acellular formulation: The final product contains no mesenchymal stem cells or live biologics, only purified matrix components such as hyaluronic acid and structural proteins.
  • Stability and shelf handling: The formulation is preserved in a stable, non-reactive format that maintains topical performance and ingredient integrity.

These factors allow Wharton’s Jelly to support visible outcomes in cosmetic skin care while remaining compliant with FDA guidelines for non-drug, non-injectable use.

Wharton’s Jelly in Ascellos™ supports skin recovery through hydration, matrix renewal, and cosmetic-only repair signals. It is processed into a stable, acellular format with no live cells or injectable components. This approach offers providers a compliant way to enhance post-procedure care using structural support and topical comfort.

Resources

Kamolz, L. P., Keck, M., & Kasper, C. (2014). Wharton’s jelly mesenchymal stem cells promote wound healing and tissue regeneration. Stem Cell Research & Therapy, 5(3), 62. https://doi.org/10.1186/scrt451

Ebrahimi, T., Tarhriz, V., Forouhandeh, H., Shariati, F. S., Sahraeian Jahromi, A., Hadian Tabarestani, M. H., Fathollahzadeh, H., & Delashoub, M. (2025). Human umbilical cord Wharton’s jelly mesenchymal cell medium progress the wound healing via cytokines and growth factors expressions. American Journal of Stem Cells, 14(1), 14–24. https://doi.org/10.62347/AMSW4025