Exosomes

A Bioactive Signal Carrier Supporting Skin Recovery and Cellular Renewal

Exosomes are nano-sized vesicles included in Ascellos™ for their role in supporting post-procedural recovery and topical skin renewal. They contain proteins, lipids, and signaling molecules that help regulate hydration, cellular activity, and visible repair. Sourced from screened perinatal tissue and processed into a non-cellular format, they are used within cosmetic guidelines for skin improvement without therapeutic claims.

What Are Exosomes?

Exosomes are nano-sized extracellular vesicles released by most cell types to facilitate communication and regulate cellular responses. In Ascellos™, they are isolated from screened perinatal tissue and processed without live cells, preserving their regenerative signaling potential in a topical, cosmetic-grade format. These vesicles deliver growth factors, cytokines, and nucleic acids that support post-procedural recovery and skin homeostasis.

How Does Exosomes Work?

Exosomes contribute to visible skin renewal by delivering bioactive signals that guide cell behavior, repair processes, and structural regeneration.

  • Cellular communication: Exosomes serve as messengers between skin cells, delivering molecular instructions that support collagen production and tissue repair.
  • Growth factors and signaling molecules: They carry cytokines, lipids, and nucleic acids that stimulate skin cell activity, promote regeneration, and enhance skin resilience.
  • Anti-inflammatory and anti-aging effects: Their signals help calm inflammation, reduce oxidative stress, and encourage matrix repair for a smoother, more youthful appearance.
  • Improved texture and tone: By stimulating dermal remodeling, exosomes help refine skin texture, reduce fine lines, and promote even pigmentation.
  • Surface renewal acceleration: Their signals enhance epidermal turnover, contributing to smoother texture and more balanced skin tone.

This activity improves skin quality and comfort during post-procedural care, aligning with cosmetic goals for firmness, clarity, and balanced regeneration.

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What Can Exosomes Do?

Topical exosomes offer multi-level cosmetic benefits by supporting structural renewal, calming inflammation, and enhancing post-procedure skin recovery.

  • Stimulate collagen and elastin production: Exosomes activate fibroblasts and signaling proteins that help reinforce dermal structure, reduce fine lines, and improve firmness over time.
  • Reduce inflammation: Their anti-inflammatory components calm redness, irritation, and flare-ups related to procedures or conditions like acne or rosacea.
  • Accelerate wound healing: Exosomes support faster resolution of surface damage by guiding cell migration and enhancing tissue remodeling.
  • Improve skin hydration: By strengthening the barrier and increasing hyaluronic acid activity, exosomes help retain moisture and support a plump, smooth appearance.
  • Enhance skin texture and tone: Their regenerative signals promote turnover and repair, refining surface texture and evening out pigmentation.
  • Reduce hyperpigmentation: Some formulations may help regulate melanin distribution, contributing to a brighter and more balanced complexion.
  • Address signs of aging: Exosomes help slow visible aging by encouraging collagen synthesis and improving skin elasticity in non-invasive care.
  • Improve skin barrier function: Their molecular content helps reinforce surface protection, improving resilience against environmental and procedural stress.

These benefits are most noticeable when exosomes are used in conjunction with microneedling or other treatments that improve topical penetration and maximize ingredient delivery.

Where Are They Used?

Exosomes in Ascellos™ are intended for topical cosmetic use only and are commonly applied after skin procedures to support healing, comfort, and visible recovery.

  • Anti-aging treatments: They help reduce the appearance of fine lines and wrinkles by supporting collagen production and improving elasticity.
  • Post-procedure healing: Applied after microneedling, laser treatments, or chemical peels to minimize redness, shorten recovery time, and calm inflammation.
  • Scar and texture improvement: They promote smoother skin by encouraging cellular renewal and balanced collagen remodeling.
  • Pigmentation and skin tone: Exosomes may help even out tone and fade discoloration through regenerative signaling.
  • Under-eye support: Used in cosmetic protocols to refresh the under-eye area, reducing puffiness and dark circles.

All exosome applications in Ascellos™ comply with FDA cosmetic regulations and are formulated for non-injectable, non-systemic use under provider supervision.

What Are The Considerations?

Exosomes used in Ascellos™ are carefully processed for cosmetic use, and their sourcing, composition, and application are aligned with current non-therapeutic guidelines.

  • Regulatory status: Exosomes are not FDA-approved for injection or systemic therapy, and in Ascellos™, they are used only topically with no treatment claims.
  • Purity and source: They are derived from rigorously screened perinatal tissues and manufactured under cGMP standards for safety, sterility, and consistency.
  • Stability: The formulation preserves vesicle integrity through controlled processing, helping maintain bioactivity until applied.
  • No live cells: Ascellos™ contains no living stem cells or cellular material, only acellular components such as exosomes, matrix proteins, and structural molecules.

These considerations support the product’s safe integration into cosmetic protocols while maintaining compliance with regulatory standards for non-drug ingredients.

Exosomes in Ascellos™ support skin recovery through non-cellular, cosmetic mechanisms. They deliver regenerative signals using stable, acellular ingredients with no live cells or unapproved biologics. This format gives providers a reliable option for improving skin quality after procedures within current cosmetic use standards.

Resources

Chen, Y., Qi, W., Wang, Z., & Niu, F. (2025). Exosome source matters: A comprehensive review from the perspective of diverse cellular origins. Pharmaceutics, 17(2), 147. https://doi.org/10.3390/pharmaceutics17020147

Wang, C. K., Tsai, T. H., & Lee, C. H. (2024). Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes. Clinical and Translational Science, 17(8), e13904. https://doi.org/10.1111/cts.13904